Bob,
I'm not sure how familiar you are with the Superman mythology, so I apologize if I tell you a lot of stuff you already know.
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1. Do you think its all over between Clark and his girlfriend, or will they be back together against soon?
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The girl Clark is in love with at this point is Lana Lang. She was Clark's high school sweetheart in the original comics before Lois Lane and she is his current love interest in Smallville. In the show, Clark and Lana were only together for a couple of days at the very end of the second season. They broke up when Clark ran away to Metropolis.
I believe it was in the Superman 3 movie that Superman's love interest was Lana Lang once again rather than Lois Lane. But in the comics, Superman and Lana never ended up together but I think they remained friends afterward.
But as to your question, I think its hard to say at this point because if the show goes on for another season or two, there's a lot that could happen. Given everything that has happened up to this point, it seems unlikely to me that Clark and Lana can get back together. Lana has already expressed that she is starting to give up hope that Clark can change from being so fickle to someone she can depend on to love her. I think that a lot would have to happen for them to get back together, but ultimately, it is Clark's refusal to share his secret with Lana that keeps them from being together. This has always been a struggle for Lana. How can you trust somebody that you know is keeping secrets from you?
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2. Who are the two billionaires (?) that the guy at the end said were Clark's real enemies? Is this guy (the one that Clark used his X-ray vision to see the bug on him) someone that Clark can trust, or does he have his own agenda?
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The guy that Clark was talking to is Lex Luthor. In the comics, Lex is Superman's arch enemy. But originally, Clark and Lex were very close friends. The details of what led to the downfall of their friendship is unknown as far as I know, and part of the Smallville show is to piece together what led to this arch rivalry. In a real way, Smallville is not only about the rise of Superman, but the fall of Lex Luthor. Clark's friendship with Lex really is the central focus of the show, even more so than Clark's relationship with Lana or his parents. So far in the show, Clark and Lex are best friends who are both keeping secrets from one another. Clark, of course, is hiding his origin and his powers from Lex, while Lex always keeps his intentions hidden. There have been various points in the series where their friendship has experienced tension on the brink of their secrets being exposed, but the bond between the two of them is very real. The final outcome, even when Lex has plummetted off the deep end of evil and Clark has risen to greatness, will be very painful for both of them.
The two billionaires are Lionel Luthor, Lex's father, and Dr. Virgil Swann, an astrophysicist who over time has somehow gained knowledge of the planet Krypton, the Krypton language, and the Krypton race. Lionel Luthor did not originally appear in the Superman comics, but was entirely made up just for the Smallville series. I can honestly say that he is my all-time favorite villain. John Glover plays the role of Lionel Luthor masterfully. Lionel is the CEO of Luthorcorp Industries, and his sinister genius has enabled him throughout the series to manipulate and blackmail person after person to acheive his ultimate desires. As Lex has said in previous episodes, Lionel views business as war. He is truly an enemy of Clark in that he is out to discover Clark's secrets and use him to satisfy his own agenda, which at this point, is surviving his terminal liver disease.
Dr. Swann, on the other hand, does not really appear to be an enemy of Clark, but there still remains an air of mystery to him and his intentions. Dr. Swann, played by Christopher Reeve, originally appeared in one episode in season two. He was the first person to tell Clark about his origins. He told Clark his real name, Kal-El, and how his home planet, Krypton, had been mysteriously destroyed. By all outward appearance, Dr. Swann has done nothing but help Clark so far. But tonight's episode suggested that some type of "arrangement" was made between Dr. Swann and Lionel Luthor. Since we do not yet know exactly what this arrangement was, I guess Dr. Swann's intentions are left up in the air. But as I said before, this is all setting up another appearance of Christopher Reeve as Dr. Swann in season four.
If you have the money and are interested in the show, I would suggest buying the first season DVD, which is currently available for probably like $40. I can't remember how much I paid for mine. I know you can pre-order season two at Amazon for $41, which comes out May 18. But if you have the money, I think it is well worth it because it is a great show and you have all the time in the world to watch all the episodes.
I'm glad I could introduce you to the show.

It's fun talking about it.