I think I'm on solid ground if I say that God is the source of natural evil. I have no problem asserting that God knits people together with defects or deformity as this is just one form of natural evil. It is all for his glory, but that does not mean that we are to just accept the way things are. That's a confusion of God's hidden will with his revealed will. Christ gave the example of healing those who have been marred by the fall. In this way we can see a glimpse of the restoration of all things breaking into this present evil age.
You haven't addressed my comparison of beauty with health. If God knits a person together with a hole in his heart, who are we to say that is unhealthy? After all, it was God's will to make him that way. If God can't make a person who is not beautiful then he can't make a person who is unhealthy.
Of course, none of what I wrote is intended to diminish the worth of a human life.
We can say that it is unhealthy because it is inherently unnatural - that is, not as designed by God before the Fall, and a result of sin.
Sin is still sin, and yet God uses that for His glory.