The first instance of the formal invocation of Mary occurs in the prayers of Ephraim Syrus († 379), addressed to Mary and the saints, and attributed by the tradition of the Syrian church, though perhaps in part incorrectly, to that author. The first more certain example appears in Gregory Nazianzen († 389), who, in his eulogy on Cyprian, relates of Justina that she besought the virgin Mary to protect her threatened virginity, and at the same time disfigured her beauty by ascetic self-tortures, and thus fortunately escaped the amours of a youthful lover (Cyprian before his conversion).But, on the other hand, the numerous writings of Athanasius, Basil, Chrysostom, and Augustine, furnish no example of an invocation of Mary. Epiphanius even condemned the adoration of Mary, and calls the practice of making offerings to her by the Collyridian women, blasphemous and dangerous to the soul.The entire silence of history respecting the worship of the Virgin down to the end of the fourth century, proves clearly that it was foreign to the original spirit of Christianity, and belongs among the many innovations of the post-Nicene age.
In the beginning of the fifth century, however, the worship of saints appeared in full bloom, and then Mary, by reason of her singular relation to the Lord, was soon placed at the head, as the most blessed queen of the heavenly host.
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